1. A domain-based vaccine construct against SARS-CoV-2, the causative agent of COVID-19 pandemic: development of self-amplifying mRNA and peptide vaccines

Mohammad Mostafa Pourseif , Sepideh Parvizpour, Behzad Jafari, Jaber Dehghani , Behrouz Naghili, Yadollah Omidi*

BioImpacts. 2021;11(1): 65-84. doi: 10.34172/bi.2021.11

PMCID: PMC7803919 PMID: 33469510 Scopus ID: 85099197264

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Immunodominant T-cell epitopes of SARS-CoV-2 spike protein with the highest population coverage were predicted by analyzing peptide binders and consensus rank (CR) score. Multi-method B-cell epitope prediction approach was used to find B-cell immunodominant regions of spike protein. Upon the high immune-potent regions of the antigen(s), self-amplifying mRNA and peptide-based vaccines were designed.

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